Two sample MR report

Telomere_length against aparc-Desikan rh volume fusiform

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0048441 0.1006337 0.9620626
Weighted median 23 -0.0477910 0.0552077 0.3866773
Inverse variance weighted 23 -0.0424058 0.0388455 0.2749864
Simple mode 23 -0.0669849 0.0787661 0.4042483
Weighted mode 23 -0.0538789 0.0601639 0.3801958

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 21.52159 21 0.4275123
Inverse variance weighted 21.69010 22 0.4785111

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0023063 0.0056876 0.6892166

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0006933 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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