Two sample MR report

Telomere_length against aparc-Desikan rh volume frontalpole

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0424876	0.1067298	0.6945853
Weighted median	23	-0.0251976	0.0522703	0.6297610
Inverse variance weighted	23	-0.0213279	0.0411557	0.6043013
Simple mode	23	-0.0245240	0.0827982	0.7698631
Weighted mode	23	-0.0148226	0.0609599	0.8101392

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.20742	21	0.2831174
Inverse variance weighted	24.69380	22	0.3119406

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039183	0.0060321	0.5230152

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007573	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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