Two sample MR report

Telomere_length against aparc-Desikan rh volume entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0261095	0.0994061	0.7953763
Weighted median	23	-0.0110793	0.0571478	0.8462777
Inverse variance weighted	23	0.0028651	0.0388455	0.9412045
Simple mode	23	-0.0422836	0.0833592	0.6170300
Weighted mode	23	-0.0155765	0.0607526	0.8000298

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.18260	21	0.5097228
Inverse variance weighted	20.24714	22	0.5675841

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014272	0.0056182	0.8019418

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006137	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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