Two sample MR report

Telomere_length against aparc-Desikan rh volume cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0021989	0.1443659	0.9879912
Weighted median	23	0.0410153	0.0639967	0.5215896
Inverse variance weighted	23	0.0051124	0.0551184	0.9261000
Simple mode	23	-0.0842811	0.1466740	0.5713813
Weighted mode	23	0.1214075	0.0924370	0.2025792

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.29510	21	0.0021409
Inverse variance weighted	44.29611	22	0.0032562

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001789	0.0081593	0.9827153

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013427	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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