Two sample MR report

Telomere_length against aparc-Desikan rh volume caudalmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1894806	0.1134648	0.1097689
Weighted median	23	-0.1066450	0.0603945	0.0774280
Inverse variance weighted	23	-0.0813043	0.0444127	0.0671524
Simple mode	23	-0.1864130	0.0960952	0.0653213
Weighted mode	23	-0.1316823	0.0651457	0.0555753

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.36113	21	0.1592170
Inverse variance weighted	28.75886	22	0.1518751

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.006642	0.0064128	0.3121001

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010042	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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