Two sample MR report

Telomere_length against aparc-Desikan rh volume caudalanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0502611	0.1167220	0.6711428
Weighted median	23	-0.0914238	0.0579459	0.1146247
Inverse variance weighted	23	-0.0300508	0.0446009	0.5004573
Simple mode	23	-0.0843636	0.0962120	0.3900425
Weighted mode	23	-0.0989941	0.0701381	0.1721083

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.95258	21	0.1151446
Inverse variance weighted	29.00136	22	0.1448218

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012409	0.0065969	0.8525994

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008969	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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