Two sample MR report

Telomere_length against aparc-Desikan rh volume bankssts

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1583016	0.1159688	0.1866888
Weighted median	23	0.0152568	0.0620324	0.8057222
Inverse variance weighted	23	0.0501286	0.0481275	0.2976065
Simple mode	23	-0.1015925	0.1306238	0.4450010
Weighted mode	23	0.0081902	0.0848137	0.9239445

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.58182	21	0.1244086
Inverse variance weighted	33.77073	22	0.0518239

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0127975	0.0065542	0.0643308

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010738	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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