Two sample MR report

Telomere_length against aparc-Desikan rh thickness transversetemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0042359	0.0994080	0.9664140
Weighted median	23	0.0141279	0.0566769	0.8031505
Inverse variance weighted	23	0.0089222	0.0388464	0.8183403
Simple mode	23	-0.0582177	0.0809828	0.4797759
Weighted mode	23	0.0014297	0.0669483	0.9831547

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.78122	21	0.4723732
Inverse variance weighted	20.80189	22	0.5330087

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008079	0.0056183	0.8870301

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006319	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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