Two sample MR report

Telomere_length against aparc-Desikan rh thickness supramarginal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1145001	0.0994057	0.2623293
Weighted median	23	-0.0722190	0.0553795	0.1922082
Inverse variance weighted	23	-0.0473919	0.0388453	0.2224588
Simple mode	23	-0.0955709	0.0973045	0.3366885
Weighted mode	23	-0.1124543	0.0671140	0.1079787

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.07235	21	0.8193038
Inverse variance weighted	15.61025	22	0.8347473

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0041205	0.0056182	0.4714171

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005182	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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