Two sample MR report

Telomere_length against aparc-Desikan rh thickness superiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1284529	0.1109009	0.2597581
Weighted median	23	-0.0630863	0.0596869	0.2905329
Inverse variance weighted	23	-0.0290817	0.0432857	0.5016759
Simple mode	23	0.1152802	0.1210125	0.3511273
Weighted mode	23	-0.0975520	0.0797275	0.2340597

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.13808	21	0.2012330
Inverse variance weighted	27.31751	22	0.1994147

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0061014	0.0062679	0.3414159

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008448	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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