Two sample MR report

Telomere_length against aparc-Desikan rh thickness superiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1415207	0.1239438	0.2663845
Weighted median	23	0.0029320	0.0601767	0.9611400
Inverse variance weighted	23	-0.0263528	0.0484553	0.5865391
Simple mode	23	0.0548891	0.1024897	0.5976374
Weighted mode	23	0.0264629	0.0886785	0.7681873

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.64847	21	0.0502633
Inverse variance weighted	34.23272	22	0.0465114

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0070713	0.0070051	0.3242441

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010512	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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