Two sample MR report

Telomere_length against aparc-Desikan rh thickness superiorfrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1422346	0.1116936	0.2167792
Weighted median	23	0.0273783	0.0583041	0.6386565
Inverse variance weighted	23	0.0229242	0.0451880	0.6119395
Simple mode	23	0.0594369	0.1078617	0.5871543
Weighted mode	23	0.0140147	0.0801367	0.8627697

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.51328	21	0.1875499
Inverse variance weighted	29.77133	22	0.1241291

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0101408	0.0063127	0.1231168

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009127	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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