Two sample MR report

Telomere_length against aparc-Desikan rh thickness rostralmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0990487	0.1307393	0.4571055
Weighted median	23	0.0368128	0.0602321	0.5410788
Inverse variance weighted	23	0.0074694	0.0508376	0.8831896
Simple mode	23	0.0620986	0.1083767	0.5724627
Weighted mode	23	0.0357529	0.0868582	0.6845982

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.32625	21	0.0200898
Inverse variance weighted	37.68144	22	0.0198878

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0065402	0.0073891	0.3861173

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011429	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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