Two sample MR report

Telomere_length against aparc-Desikan rh thickness rostralanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1230963	0.1136181	0.2909044
Weighted median	23	-0.0635347	0.0565955	0.2616036
Inverse variance weighted	23	-0.0296985	0.0441946	0.5015867
Simple mode	23	-0.1266765	0.0919626	0.1822180
Weighted mode	23	-0.0884473	0.0638789	0.1800554

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.43394	21	0.1569473
Inverse variance weighted	28.47581	22	0.1604436

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0057346	0.0064214	0.3819545

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008806	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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