Two sample MR report

Telomere_length against aparc-Desikan rh thickness precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2122443	0.1025065	0.0509189
Weighted median	23	-0.0491957	0.0591584	0.4056389
Inverse variance weighted	23	-0.0456606	0.0419403	0.2762846
Simple mode	23	-0.0536620	0.0969209	0.5853898
Weighted mode	23	-0.0568540	0.0801250	0.4854262

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.33154	21	0.3806254
Inverse variance weighted	25.64612	22	0.2671855

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0102283	0.0057935	0.0920197

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000819	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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