Two sample MR report

Telomere_length against aparc-Desikan rh thickness precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2119387	0.1353242	0.1322579
Weighted median	23	0.0117029	0.0591443	0.8431467
Inverse variance weighted	23	-0.0142640	0.0546758	0.7941829
Simple mode	23	0.0646793	0.0991857	0.5210904
Weighted mode	23	-0.0014881	0.0749949	0.9843477

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.91954	21	0.0100348
Inverse variance weighted	43.58684	22	0.0039930

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0121372	0.0076482	0.1274717

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013248	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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