Two sample MR report

Telomere_length against aparc-Desikan rh thickness postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2309465	0.0994046	0.0302849
Weighted median	23	-0.1017093	0.0549058	0.0639637
Inverse variance weighted	23	-0.0446725	0.0388450	0.2501354
Simple mode	23	-0.1289492	0.1056995	0.2353968
Weighted mode	23	-0.1347784	0.0693172	0.0647470

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.57381	21	0.7365951
Inverse variance weighted	20.71817	22	0.5382095

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0114372	0.0056181	0.0545847

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006679	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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