Two sample MR report

Telomere_length against aparc-Desikan rh thickness pericalcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2099374	0.0994063	0.0468472
Weighted median	23	-0.0263595	0.0517289	0.6103535
Inverse variance weighted	23	0.0133634	0.0388456	0.7308363
Simple mode	23	-0.0460631	0.0856955	0.5963038
Weighted mode	23	-0.0432703	0.0579431	0.4631075

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.35211	21	0.9554834
Inverse variance weighted	17.30761	22	0.7461607

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0137106	0.0056182	0.0236211

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005281	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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