Two sample MR report

Telomere_length against aparc-Desikan rh thickness parstriangularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0361758	0.0994064	0.7195573
Weighted median	23	0.0289421	0.0582197	0.6191056
Inverse variance weighted	23	-0.0039872	0.0388455	0.9182459
Simple mode	23	0.0625270	0.1042450	0.5547624
Weighted mode	23	0.0123290	0.0695787	0.8609764

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.84750	21	0.5949224
Inverse variance weighted	19.04016	22	0.6428474

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002466	0.0056182	0.6651953

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005773	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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