Two sample MR report

Telomere_length against aparc-Desikan rh thickness parsorbitalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0796745	0.0994080	0.4318239
Weighted median	23	-0.0252808	0.0590142	0.6683710
Inverse variance weighted	23	-0.0621753	0.0388465	0.1094787
Simple mode	23	-0.0699199	0.1081640	0.5246911
Weighted mode	23	-0.0497243	0.0830015	0.5552408

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.38188	21	0.5606572
Inverse variance weighted	19.41845	22	0.6193664

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010745	0.0056184	0.8501738

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006661	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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