Two sample MR report

Telomere_length against aparc-Desikan rh thickness parsopercularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0456746	0.0996713	0.6514783
Weighted median	23	0.0486671	0.0571919	0.3948012
Inverse variance weighted	23	0.0569528	0.0388454	0.1426100
Simple mode	23	-0.0229351	0.0951670	0.8117880
Weighted mode	23	0.0228877	0.0691666	0.7438463

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.11214	21	0.4521143
Inverse variance weighted	21.12733	22	0.5128811

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006925	0.0056332	0.9033319

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007054	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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