Two sample MR report

Telomere_length against aparc-Desikan rh thickness parahippocampal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1638666	0.1032552	0.1274552
Weighted median	23	0.0257416	0.0566725	0.6496727
Inverse variance weighted	23	0.0501474	0.0439239	0.2535841
Simple mode	23	0.0633113	0.0948711	0.5114951
Weighted mode	23	0.0133278	0.0609346	0.8288823

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.65789	21	0.3624864
Inverse variance weighted	28.12839	22	0.1714653

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0131403	0.0058357	0.0351718

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009029	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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