Two sample MR report

Telomere_length against aparc-Desikan rh thickness paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2186093	0.0994044	0.0392052
Weighted median	23	0.0003904	0.0561821	0.9944551
Inverse variance weighted	23	-0.0233465	0.0391438	0.5508893
Simple mode	23	0.0173449	0.0933749	0.8543390
Weighted mode	23	0.0083768	0.0760756	0.9133197

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.78571	21	0.6625221
Inverse variance weighted	22.33972	22	0.4397747

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0119892	0.0056181	0.0447941

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006879	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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