Two sample MR report

Telomere_length against aparc-Desikan rh thickness middletemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0972634	0.1010143	0.3465712
Weighted median	23	0.1208925	0.0574972	0.0355023
Inverse variance weighted	23	0.0813514	0.0418176	0.0517284
Simple mode	23	0.1339140	0.1020223	0.2028488
Weighted mode	23	0.0919519	0.0746017	0.2307458

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.68515	21	0.4178438
Inverse variance weighted	25.49561	22	0.2739662

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0109669	0.0057091	0.0684174

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009055	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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