Two sample MR report

Telomere_length against aparc-Desikan rh thickness medialorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0212830	0.1209639	0.8620225
Weighted median	23	-0.0210248	0.0629586	0.7384204
Inverse variance weighted	23	-0.0100380	0.0462703	0.8282535
Simple mode	23	-0.1473540	0.1387842	0.2998667
Weighted mode	23	-0.1835154	0.1538361	0.2456049

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.09834	21	0.0720369
Inverse variance weighted	31.21551	22	0.0917892

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019231	0.0068367	0.7812366

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009479	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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