Two sample MR report

Telomere_length against aparc-Desikan rh thickness lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2274045	0.1068115	0.0452502
Weighted median	23	0.0017930	0.0560358	0.9744737
Inverse variance weighted	23	0.0154278	0.0463255	0.7391115
Simple mode	23	-0.0217451	0.1078414	0.8420513
Weighted mode	23	-0.0293275	0.0633289	0.6478424

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.24584	21	0.2813001
Inverse variance weighted	31.28888	22	0.0903540

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0149098	0.0060367	0.0221734

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009529	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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