Two sample MR report

Telomere_length against aparc-Desikan rh thickness lateralorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0049638	0.1115886	0.9649395
Weighted median	23	0.0073003	0.0562146	0.8966734
Inverse variance weighted	23	0.0037410	0.0426107	0.9300390
Simple mode	23	0.0274729	0.0829702	0.7436889
Weighted mode	23	0.0008820	0.0621696	0.9888081

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.46268	21	0.1893534
Inverse variance weighted	26.47173	22	0.2319800

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0005345	0.0063067	0.9332653

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008024	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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