Two sample MR report

Telomere_length against aparc-Desikan rh thickness lateraloccipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1551330	0.1076482	0.1642990
Weighted median	23	-0.0836524	0.0549196	0.1277136
Inverse variance weighted	23	-0.0456272	0.0422773	0.2804826
Simple mode	23	-0.0909365	0.0969654	0.3585170
Weighted mode	23	-0.0944667	0.0625544	0.1452346

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.62694	21	0.2636828
Inverse variance weighted	26.05919	22	0.2491494

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0067236	0.006084	0.2816044

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008314	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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