Two sample MR report

Telomere_length against aparc-Desikan rh thickness isthmuscingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0318981	0.1174621	0.7886113
Weighted median	23	-0.0270237	0.0565764	0.6328999
Inverse variance weighted	23	-0.0180975	0.0448630	0.6866569
Simple mode	23	-0.0116521	0.0917515	0.9000973
Weighted mode	23	-0.0078043	0.0637867	0.9037325

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.32143	21	0.1064958
Inverse variance weighted	29.34418	22	0.1352942

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008474	0.0066387	0.8996494

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008957	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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