Two sample MR report

Telomere_length against aparc-Desikan rh thickness insula

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0087030	0.1419570	0.9516942
Weighted median	23	0.0068031	0.0590469	0.9082743
Inverse variance weighted	23	0.0082109	0.0542192	0.8796291
Simple mode	23	-0.0418538	0.0989756	0.6764948
Weighted mode	23	0.0244119	0.0672153	0.7199294

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.82663	21	0.0033075
Inverse variance weighted	42.86080	22	0.0049088

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010385	0.008023	0.8982409

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013001	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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