Two sample MR report

Telomere_length against aparc-Desikan rh thickness inferiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0859214	0.1276127	0.5081004
Weighted median	23	0.0149693	0.0633325	0.8131526
Inverse variance weighted	23	-0.0490649	0.0488356	0.3150432
Simple mode	23	-0.0934850	0.1008392	0.3639495
Weighted mode	23	0.0894430	0.1067839	0.4112588

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.61020	21	0.0311431
Inverse variance weighted	34.77245	22	0.0409183

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.002263	0.0072124	0.7567957

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011018	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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