Two sample MR report

Telomere_length against aparc-Desikan rh thickness inferiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0467762	0.1120945	0.6806996
Weighted median	23	0.0133294	0.0566014	0.8138244
Inverse variance weighted	23	-0.0183439	0.0428739	0.6687556
Simple mode	23	0.0187874	0.0852665	0.8276399
Weighted mode	23	0.0071442	0.0809192	0.9304464

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.70329	21	0.1808912
Inverse variance weighted	26.79985	22	0.2189273

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017457	0.0063353	0.7855818

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008187	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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