Two sample MR report

Telomere_length against aparc-Desikan rh thickness fusiform

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1748930	0.1270510	0.1831499
Weighted median	23	-0.0696400	0.0584139	0.2331898
Inverse variance weighted	23	-0.0574662	0.0496577	0.2471722
Simple mode	23	-0.0979732	0.0985267	0.3308489
Weighted mode	23	-0.0665969	0.0719654	0.3647979

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.30575	21	0.0335991
Inverse variance weighted	35.95275	22	0.0307222

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0072099	0.0071806	0.3267659

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011557	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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