Two sample MR report

Telomere_length against aparc-Desikan rh thickness frontalpole

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1150563	0.0994060	0.2600891
Weighted median	23	-0.0026438	0.0560859	0.9624024
Inverse variance weighted	23	-0.0227585	0.0388456	0.5579616
Simple mode	23	0.0184176	0.1053134	0.8627704
Weighted mode	23	-0.0056892	0.0788799	0.9431545

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.96107	21	0.7134631
Inverse variance weighted	17.97855	22	0.7072594

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056671	0.0056183	0.3246007

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005552	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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