Two sample MR report

Telomere_length against aparc-Desikan rh thickness entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1053607	0.1299597	0.4266206
Weighted median	23	-0.0615671	0.0569560	0.2797150
Inverse variance weighted	23	-0.0587365	0.0497966	0.2381873
Simple mode	23	-0.0572536	0.0838463	0.5018360
Weighted mode	23	-0.0572536	0.0622515	0.3676972

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.89375	21	0.0224736
Inverse variance weighted	36.15339	22	0.0292364

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0028627	0.007345	0.7006468

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011647	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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