Two sample MR report

Telomere_length against aparc-Desikan rh thickness cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1292948	0.1190573	0.2897937
Weighted median	23	-0.0116758	0.0576580	0.8395249
Inverse variance weighted	23	-0.0066814	0.0467899	0.8864518
Simple mode	23	-0.1620500	0.1064077	0.1420257
Weighted mode	23	-0.0449539	0.0721758	0.5397934

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.12363	21	0.0895318
Inverse variance weighted	31.91926	22	0.0787831

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0075284	0.0067288	0.2758476

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009681	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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