Two sample MR report

Telomere_length against aparc-Desikan rh thickness caudalmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0973932	0.1242616	0.4419231
Weighted median	23	-0.0287633	0.0596544	0.6296884
Inverse variance weighted	23	-0.0090142	0.0481115	0.8513782
Simple mode	23	0.1314349	0.1106072	0.2473841
Weighted mode	23	-0.0096937	0.0696089	0.8905121

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.81551	21	0.0483032
Inverse variance weighted	33.74844	22	0.0520931

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054264	0.007023	0.4483268

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010243	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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