Two sample MR report

Telomere_length against aparc-Desikan rh thickness caudalanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1081763	0.1172843	0.3668261
Weighted median	23	-0.0752597	0.0552725	0.1733199
Inverse variance weighted	23	-0.0245479	0.0454136	0.5888231
Simple mode	23	-0.0928382	0.0926205	0.3270728
Weighted mode	23	-0.0895356	0.0603816	0.1523045

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.23219	21	0.1085377
Inverse variance weighted	30.06748	22	0.1168335

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0051348	0.0066287	0.4471903

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009232	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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