Two sample MR report

Telomere_length against aparc-Desikan rh thickness GlobalMeanThickness

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1839995	0.1137589	0.1207043
Weighted median	23	-0.0064465	0.0592339	0.9133360
Inverse variance weighted	23	-0.0236378	0.0457935	0.6057265
Simple mode	23	0.0477156	0.0969186	0.6273659
Weighted mode	23	0.0106278	0.0817239	0.8977125

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.50342	21	0.1548048
Inverse variance weighted	30.57501	22	0.1051452

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0098463	0.0064294	0.1405886

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009376	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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