Two sample MR report

Telomere_length against aparc-Desikan rh area transversetemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1998125	0.0994072	0.0574472
Weighted median	23	-0.0758636	0.0548781	0.1668488
Inverse variance weighted	23	-0.0261363	0.0392472	0.5054493
Simple mode	23	-0.0404755	0.1025389	0.6968405
Weighted mode	23	-0.0930175	0.0645433	0.1636210

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.85408	21	0.5945000
Inverse variance weighted	22.45665	22	0.4329319

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0106637	0.0056183	0.0715223

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006942	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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