Two sample MR report

Telomere_length against aparc-Desikan rh area supramarginal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0101680	0.1462329	0.9452231
Weighted median	23	-0.0968460	0.0606455	0.1102836
Inverse variance weighted	23	-0.0470587	0.0560700	0.4013094
Simple mode	23	-0.1233855	0.1104620	0.2760474
Weighted mode	23	-0.1066941	0.0768938	0.1791690

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	45.44645	21	0.0015128
Inverse variance weighted	45.83761	22	0.0020749

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0035137	0.0082647	0.6750562

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014333	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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