Two sample MR report

Telomere_length against aparc-Desikan rh area superiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0311641	0.1108464	0.7813492
Weighted median	23	-0.0807386	0.0561592	0.1505271
Inverse variance weighted	23	-0.0729126	0.0424883	0.0861505
Simple mode	23	-0.1247339	0.0935364	0.1960007
Weighted mode	23	-0.0900463	0.0616639	0.1583486

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.11195	21	0.2022126
Inverse variance weighted	26.32012	22	0.2381917

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025633	0.0062648	0.6865597

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009043	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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