Two sample MR report

Telomere_length against aparc-Desikan rh area superiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0573818	0.0995688	0.5705362
Weighted median	23	0.0525386	0.0594331	0.3766993
Inverse variance weighted	23	0.0017675	0.0388452	0.9637078
Simple mode	23	-0.0999602	0.1160744	0.3984316
Weighted mode	23	0.1091945	0.0814867	0.1939132

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.06904	21	0.4547346
Inverse variance weighted	21.43846	22	0.4938003

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034147	0.0056274	0.550488

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006497	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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