Two sample MR report

Telomere_length against aparc-Desikan rh area superiorfrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0354214	0.1189035	0.7687068
Weighted median	23	-0.0451819	0.0613508	0.4614561
Inverse variance weighted	23	-0.0535446	0.0454258	0.2385067
Simple mode	23	-0.0656435	0.0987329	0.5130502
Weighted mode	23	-0.0533468	0.0683379	0.4433376

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.04611	21	0.0910653
Inverse variance weighted	30.08534	22	0.1164049

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0011128	0.0067202	0.8700661

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009692	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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