Two sample MR report

Telomere_length against aparc-Desikan rh area rostralmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0685810	0.1216106	0.5787689
Weighted median	23	-0.0567734	0.0553094	0.3046705
Inverse variance weighted	23	-0.0543868	0.0477452	0.2546592
Simple mode	23	-0.0530831	0.0996631	0.5996323
Weighted mode	23	-0.0491664	0.0607626	0.4270906

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.42983	21	0.0667959
Inverse variance weighted	33.23588	22	0.0586320

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0075502	0.0068731	0.2844185

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010664	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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