Two sample MR report

Telomere_length against aparc-Desikan rh area rostralanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0242475	0.0994076	0.8096601
Weighted median	23	-0.0207087	0.0527735	0.6947580
Inverse variance weighted	23	-0.0102287	0.0388461	0.7923092
Simple mode	23	-0.0300431	0.0778048	0.7031064
Weighted mode	23	-0.0300431	0.0611418	0.6280328

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.75146	21	0.6646735
Inverse variance weighted	17.89342	22	0.7122883

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0021168	0.0056183	0.710121

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005443	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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