Two sample MR report

Telomere_length against aparc-Desikan rh area precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1736712	0.1211880	0.1665577
Weighted median	23	-0.0612024	0.0596975	0.3052648
Inverse variance weighted	23	-0.0114355	0.0485426	0.8137615
Simple mode	23	-0.0072280	0.1087115	0.9475902
Weighted mode	23	-0.0637007	0.0825345	0.4484408

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.21225	21	0.0701974
Inverse variance weighted	34.35597	22	0.0451778

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0099612	0.0068492	0.160633

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010436	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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