Two sample MR report

Telomere_length against aparc-Desikan rh area precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0247920	0.1050009	0.8156330
Weighted median	23	-0.0194758	0.0552418	0.7244219
Inverse variance weighted	23	-0.0469164	0.0401380	0.2424532
Simple mode	23	-0.0096536	0.0888671	0.9144813
Weighted mode	23	-0.0217072	0.0613103	0.7266687

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.43012	21	0.3214808
Inverse variance weighted	23.48858	22	0.3745954

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0013584	0.0059344	0.8211554

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007559	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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