Two sample MR report

Telomere_length against aparc-Desikan rh area posteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1697215	0.1425389	0.2470561
Weighted median	23	-0.0168024	0.0559746	0.7640412
Inverse variance weighted	23	-0.0588881	0.0582204	0.3117916
Simple mode	23	-0.1118970	0.0862980	0.2081928
Weighted mode	23	-0.0394559	0.0621349	0.5319758

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.17816	21	0.0029829
Inverse variance weighted	49.42026	22	0.0007020

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0140364	0.0080559	0.0960697

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015669	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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