Two sample MR report

Telomere_length against aparc-Desikan rh area postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0418480	0.1140916	0.7174435
Weighted median	23	-0.0101025	0.0665018	0.8792555
Inverse variance weighted	23	-0.0485646	0.0435632	0.2649328
Simple mode	23	0.0336436	0.1312883	0.8001331
Weighted mode	23	0.0303954	0.0856727	0.7261289

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.66331	21	0.1499612
Inverse variance weighted	27.66869	22	0.1869223

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0004124	0.0064482	0.9496103

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008858	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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